SLIGKV-NH2, PAR2 receptor agonist, 5mg, Tocris Bioscience. Ki=9.64 M, IC50=10.4 M. Sequence: Ser-Leu-Ile-Gly-Lys-Val-NH2. Corresponds to tethered ligand exposed by trypsin cleavage of PAR-2.
SLIGKV-NH2, PAR2 receptor agonist, 5mg, Tocris Bioscience. Ki=9.64 M, IC50=10.4 M. Sequence: Ser-Leu-Ile-Gly-Lys-Val-NH2. Corresponds to tethered ligand exposed by trypsin cleavage of PAR-2.
Purmorphamine, Smo receptor agonist, 10mg, activates Hedgehog pathway, induces osteogenesis in mouse mesenchymal progenitor cells, transdifferentiates pre-adipocytes and myoblasts with BMP-4, induces osteoblast and spinal motor neuron differentiation